BLD Insights
Indazole Derivatives
17 April 2024
1H-Indazole
5-Bromo-1H-indazole
6-Bromo-1H-indazole
Indazole-3-carboxylic acid
4-Bromo-1H-indazole
1H-Indazol-3-amine
3-Bromo-1H-indazole
5-Bromo-1-methyl-1H-indazole
1H-Indazol-6-amine
7-Bromo-1H-indazole
The indazole scaffold is commonly found in drugs. Modifying active indazole derivatives based on structure-activity relationships can help obtain more potent lead compounds or clinical drugs. FDA-approved drugs such as axitinib, entrectinib and granisetron are used to treat renal cell carcinoma, non-small cell lung cancer, and chemotherapy-induced nausea and vomiting.
The indazole has the following functions in drugs:
◆ Pharmaceutical Active Modulating
◆ Drug Resistance Reducing
◆ Pharmacokinetic Improving
◆ Selectivity Increasing
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