BLD Insights
1-Cyclopropyl-1H-pyrazole
01 April 2024
Ethyl 1-cyclopropyl-3-methyl-1H-pyrazole-5-carboxylate
1-Cyclopropyl-4-iodo-1H-pyrazole
1-Cyclopropyl-1H-pyrazole-5-carboxylic acid
4-Bromo-1-cyclopropyl-1H-pyrazole
1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-Cyclopropyl-1H-pyrazole-4-carbaldehyde
1-Cyclopropyl-1H-pyrazole
5-Bromo-1-cyclopropyl-1H-pyrazole
1-Cyclopropyl-1H-pyrazole-4-carboxylic acid
5-Chloro-1-cyclopropyl-4-nitro-1H-pyrazole
Pyrazole and its derivatives have pharmacological activities such as anti-microbial, anti-tumor, anti-viral, anti-depression, etc. The introduction of other cyclic groups on pyrazole can generate a large number of lead compounds, among which the introduction of cyclopropyl plays a variety of roles in drug molecules:
◆ Plasma clearance reducing
◆ Off-target effects decreasing
◆ Blood-brain barrier permeability increasing
◆ Receptor affinity enhancing
◆ Peptide hydrolysis limiting
◆ Drug dissociation improving
It is currently being widely used in drug research by companies such as Merck & Co., Inc. and Hansoh Pharma.
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